Certain medications can help improve sexual performance and prolong activity when used under medical supervision. PDE5 inhibitors like Sildenafil, Tadalafil, and Vardenafil enhance erectile function, helping maintain erections during intercourse. For delaying ejaculation specifically, short-acting SSRIs like Dapoxetine or topical anaesthetic sprays/creams can reduce penile sensitivity and help prolong sexual activity. These treatments should only be used after consulting a doctor or urologist, who can recommend the correct option and dose while ensuring safety, as all may have side effects or interact with other health conditions. Self-medication is not advised, as it may lead to undesirable effects. Additionally, combining these with behavioural techniques or lifestyle measures can further enhance sexual performance safely.