It sounds like you're asking about using a product for facial pigmentation without a prescription, twice a week at night.

When considering using any skin product for pigmentation without a prescription, it's important to be cautious.

• Identify the product: Knowing the active ingredients helps determine safety and suitability.
• Frequency and timing: Using a product twice a week at night is generally safer than daily use, but this depends on the product's strength.
• Potential side effects: Some pigmentation treatments can cause irritation or sensitivity, especially without professional guidance.
• Consultation: Ideally, consult a dermatologist to ensure the product is appropriate for your skin type and pigmentation cause.

If you decide to proceed without a prescription, start with a patch test to check for any adverse reactions. Also, always use sunscreen during the day, as pigmentation can worsen with sun exposure. If you notice any irritation, redness, or worsening pigmentation, discontinue use and seek medical advice.

For personalized advice and safe treatment options, please consult a dermatologist.