Tretin 0.05% cream may commonly cause skin dryness, irritation, and discomfort, particularly during the initial weeks of treatment as the skin adapts to the medication. This occurs because tretinoin increases skin cell turnover, which can temporarily disrupt the skin's natural barrier, leading to dryness, redness, peeling, or pain. Using excessive amounts, applying it too frequently, or combining it with other harsh skincare products can worsen these effects. If you experience significant pain or persistent irritation, it is advisable to stop using the cream temporarily and consult a dermatologist. Your doctor may suggest adjusting the dosage, reducing the frequency of application, or switching to a lower-strength or alternative treatment better suited to your skin's tolerance.