1. Metformin: Generally safe for diabetes management but requires caution if there is kidney or heart failure.

2. Glimepiride: Effective in lowering blood sugar but may cause hypoglycemia, especially in older adults.

3. Pioglitazone: Can impact heart health and may cause fluid retention, potentially worsening heart failure.

Recommendation: Due to the heart condition, Pioglitazone may not be suitable or may need close monitoring. Consult your doctor or cardiologist to ensure this medication is safe and appropriate for your specific health needs. They may suggest alternative treatments or additional monitoring.