Generalized itching (pruritus) is most likely a drug-related allergic or hypersensitivity reaction, which can occur with anticoagulants such as Xarelto 15 mg Tablet (rivaroxaban). In some patients, these medications may also cause changes in liver enzymes, which can contribute to pruritus. You should inform your doctor promptly so the medication can be reviewed or changed if needed, and to rule out liver dysfunction or other allergic causes. If the itching is accompanied by a rash, swelling, or breathing difficulty, seek urgent medical attention.