Fever in children with G6PD deficiency should be managed carefully because some medicines can trigger breakdown of red blood cells in sensitive children. Ibugesic contains ibuprofen, and although many children with G6PD deficiency may tolerate it, doctors usually prefer caution because reactions can vary from child to child. Paracetamol is often considered a safer option for reducing fever when used in the correct dose for the child?s weight. Keep your daughter well hydrated, let her rest, and monitor the fever closely. Sponging with normal water may also help make her more comfortable. It is important to check the exact cause of the fever because infections themselves can sometimes trigger problems in children with G6PD deficiency. A paediatrician can guide you about the safest medicine and the correct dose based on the child's age, weight, and medical history. Seek urgent medical care if she develops unusual tiredness, yellowing of the eyes, dark urine, breathing difficulty, or persistent high fever.