My father has a creatinine level of 1.5 mg/dL and an HbA1c of 8.5%. His doctor has prescribed Istamet 50/500 mg for type 2 diabetes. Will this medicine affect his kidneys? | Apollo Pharmacy

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My father has a creatinine level of 1.5 mg/dL and an HbA1c of 8.5%. His doctor has prescribed Istamet 50/500 mg for type 2 diabetes. Will this medicine affect his kidneys?

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My father has a creatinine level of 1.5 mg/dL and an HbA1c of 8.5%. His doctor has prescribed Istamet 50/500 mg for type 2 diabetes. Will this medicine affect his kidneys?

Asked by Female, 29 · 2 days ago

Bayyarapu Mahesh Kumar

M Pharmacy

1 day ago

Istamet 50/500 mg is a prescription medicine used to help manage type 2 diabetes. Whether it is suitable depends on factors such as kidney function, overall health, and other medical conditions. Since your father's doctor has evaluated him and prescribed this medicine, it is important to follow the prescribed treatment and attend regular follow-up appointments so that kidney function and blood sugar can be monitored as needed. If you have concerns about its effect on the kidneys, discuss them with the treating doctor, who can explain why this medicine was chosen and whether any dose adjustments or monitoring are required based on your father's kidney function. Do not stop or change the medication without medical advice.

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I am currently taking Istamet for diabetes, and my blood sugar levels are 120/150 mg/dL. Since this medication is expensive, what are some cost-effective alternative medicines or generic substitutes I can use?

Your current blood sugar levels of 120/150 mg/dL are excellent and show your treatment is highly effective. To manage costs, you can safely switch to generic equivalents. Your current medication, Istamet, is a combination of two active ingredients: sitagliptin and metformin. Generic versions contain the same active components, offering the same efficacy and safety at a much lower price. Please consult your prescribing doctor before making any changes. They can easily write you a prescription for a cost-effective generic alternative of sitagliptin and metformin to ensure your transition is seamless, safe, and pocket-friendly.

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Your current medication, Istamet 50/1000, is a combination of two active ingredients: sitagliptin and metformin. A highly effective and much more affordable alternative is the generic version of this exact combination (generic sitagliptin/metformin). This generic equivalent works identically to Istamet 50/1000 and is completely safe to take with your high blood pressure. Please consult your healthcare provider to discuss switching to the generic form to help lower your expenses while keeping your blood sugar and blood pressure safely managed.

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I have been taking two tablets of Glyree 2 and Thyrox 50 mg on an empty stomach, and Istamet 50/1000 after dinner for the past 15 months. Based on my recent blood report, do I need to make any changes to my current medications?

Without reviewing your recent blood sugar and thyroid test results, it is not possible to safely recommend any changes to your current medications. Continue taking your prescribed medicines as directed and follow a healthy diet, regular exercise routine, and blood sugar monitoring. Please consult your treating doctor and share your latest HbA1c, fasting/post-meal blood sugar, and thyroid test results for personalized treatment advice. Do not change or stop any medication without medical supervision.

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Is it safe and clinically appropriate to discontinue diabetes medication, such as Istamet 50/500, for a patient with type 2 diabetes whose HbA1c has stabilized between 5.9% and 6.0% (estimated average glucose of 122?125 mg/dL), and what monitoring protocol should be followed after stopping treatment?

Your HbA1c has stabilized at such a healthy level of 5.9% to 6.0%! While it may be possible to safely reduce or discontinue your medication, Istamet (sitagliptin/metformin), this must be done gradually and under your doctor's close supervision. Stopping abruptly can cause your blood sugar to rise again. If your doctor agrees to a trial discontinuation, you should monitor your fasting and post-meal blood glucose daily at first, and check your HbA1c again in three months. Maintaining a balanced diet and regular exercise is key to keeping these great numbers. Please consult your physician before making any changes.

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What are the potential long-term side effects and clinical implications of daily, multi-year use of Istamet (metformin/sitagliptin) 1000 mg in a patient with well-controlled blood glucose levels?

For long-term use of Istamet (metformin/sitagliptin), the outlook is generally very positive. Metformin is highly safe for multi-year use, though it can sometimes lower Vitamin B12 levels over time, so having your doctor check your B12 levels periodically is a good idea. Sitagliptin is also well-tolerated long-term. Since your blood sugar is stable, this combination is doing its job beautifully. Continue regular check-ups with your doctor to monitor your kidney function and overall health.

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I have diabetes and want quicker control over it. What can I do now?

Diabetes is usually due to high blood sugar from how the body handles insulin, and it needs steady control rather than quick fixes. Follow a regular meal routine with balanced portions and limit sugary and refined foods so your blood sugar stays stable, and stay active with daily walking or light exercise to help your body use sugar more efficiently. Take your medicines as advised, check your blood sugar regularly to understand your control, and maintain proper sleep and manage stress, as they can affect your levels. Avoid skipping meals or sudden diet changes, as this can disturb control. If you feel unusual weakness, dizziness, or very high readings, talk to your doctor to adjust your plan for better control.

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