1. Overview of Medications

• Brivaracetam (Brevipil) and Levetiracetam (Levera) are both antiepileptic drugs used to treat epilepsy by reducing the frequency of seizures.

2. Mechanism of Action

• Brivaracetam works by modulating synaptic vesicle protein 2A (SV2A) in the brain, which helps reduce abnormal electrical activity.
• Levetiracetam also targets SV2A but has a slightly different binding profile, slowing down abnormal brain signals that cause seizures.

3. Dosage and Strength

• Brevipil is commonly available as 50 mg tablets.
• Levera is available in 500 mg tablets, with dosing tailored by the doctor based on the patient’s condition.

4. Efficacy and Clinical Use

• Both medications are effective in controlling seizures, but Brivaracetam may be preferred in some cases due to its potency and possibly fewer behavioral side effects.
• Levetiracetam is widely used and effective for various types of seizures but may cause behavioral changes, especially in younger patients.

5. Side Effects and Safety Profile

• Common side effects of both include dizziness, sleepiness, and weakness.
• Levetiracetam may cause behavioral changes such as aggression or mood swings, particularly in children and adolescents.
• Both drugs require caution with activities needing focus, like driving.

6. Cost and Availability

• Levera (Levetiracetam) is generally more affordable and widely available in India.
• Brevipil (Brivaracetam) may be more expensive and less commonly stocked.

7. Medical Advice

• It is important to consult a neurologist to determine which medication suits your specific type of epilepsy, medical history, and lifestyle. The doctor will guide the choice and dosing to optimize seizure control and minimize side effects.

If you experience any side effects or changes in mood, please seek medical advice promptly. For emergencies, contact Apollo Emergency at 1066.