These medicines are commonly used for long-term management of bipolar disorder and are effective in preventing manic or depressive episodes. However, like all medicines, they can have side effects. Qutipin (Quetiapine) may cause sleepiness, weight gain, increased blood sugar, and increased cholesterol. Divakote (Divalproex) may sometimes affect the liver, cause weight gain, tremors, or stomach upset. Litca SR-450 (Lithium) may cause increased thirst, frequent urination, loss of appetite, dizziness, dry mouth, changes in taste, blurred vision, and shaky movements. Most patients tolerate these medicines well when they are monitored regularly. It is important not to stop or change doses on your own. If side effects occur, your doctor may adjust doses or switch to other options such as different mood stabilisers or newer antipsychotic medicines. Overall, these medicines remain the safest and most effective option when properly monitored.