Lobate-GM Neo Cream is a strong combination cream and is generally not recommended for use on the face unless a doctor specifically advises it. If a doctor has prescribed it for facial use, it is usually applied once daily, preferably at night, in a very thin layer for a short duration only. Avoid the eyes, lips, and surrounding areas. Do not use it on the face without medical advice, as improper use can cause side effects like skin thinning or irritation.