Lokelma Powder for Oral Suspension, containing sodium zirconium cyclosilicate, is generally well tolerated, and not all patients experience side effects. However, some individuals may develop adverse effects depending on their underlying medical conditions, kidney and heart function, dosage, and overall response to treatment. The most commonly reported side effect is edema or swelling of the feet and ankles due to its sodium content, especially in patients with heart failure or chronic kidney disease. Hypokalemia may occur if potassium levels drop excessively, which can cause muscle weakness, cramps, or cardiac rhythm changes, so regular monitoring of serum potassium is recommended. Mild gastrointestinal symptoms such as constipation or abdominal discomfort may also occur. Rare allergic reactions are possible and require immediate medical attention. Regular follow up with electrolyte monitoring helps ensure safe and effective treatment.