Lora 10 tablets contain loratadine, which is an antihistamine commonly used to relieve itching caused by allergies, such as skin rashes or hives. In general, it is considered safe for most adults to take it again if they have used it before without any side effects, provided it is taken in the correct dose. However, itching around the buttocks can have several causes, and not all of them improve with antihistamines. Common reasons include skin irritation from sweating, fungal infection, piles, worm infestation, or contact dermatitis from soaps or clothing. If the cause is not allergy-related, loratadine may give only partial or temporary relief. It is important to maintain good hygiene, keep the area clean and dry, and avoid scratching as much as possible. If the itching persists for more than a few days, becomes severe, or is accompanied by rashes, pain, or discharge, you should consult a doctor for a thorough examination and targeted treatment. Self-treatment should not be continued long-term without medical advice.