Painful bumps on the penis can stem from several common and highly treatable conditions, such as infected hair follicles (folliculitis), genital herpes, or viral warts. Because different conditions require entirely different treatments, you should avoid self-treating with over-the-counter creams. If it is a bacterial infection, a generic topical antibiotic like mupirocin may be prescribed. For viral causes, generic antiviral creams like acyclovir or specific local treatments are used. Please do not squeeze or pop them, as this can spread infection. I highly recommend visiting a healthcare provider or urologist for a quick, accurate diagnosis and the correct prescription.