The standard and most common drug combination used to treat Diffuse Large B-Cell Lymphoma (DLBCL) is a regimen called R-CHOP. This includes: Rituximab (an immunotherapy), Cyclophosphamide, Doxorubicin, and Vincristine (three chemotherapy medicines), and Prednisone (a steroid). For cases where the cancer returns or doesn't respond to R-CHOP, doctors may use other treatments. These can include targeted therapy drugs like Polatuzumab vedotin, different chemotherapy regimens, or advanced immunotherapy like CAR-T cell therapy. Your oncologist will customise the exact plan based on your health and cancer stage.