Spiramycin is used to prevent the transmission of toxoplasmosis to the baby. Whether your wife needs to continue it depends on whether she has an active, recent infection or an old, inactive one. If her infection is historical (acquired long before pregnancy), treatment is typically unnecessary because her immunity protects the baby. If it is a recent infection, she should continue. I recommend consulting a maternal-fetal medicine specialist to review her antibody tests (IgG/IgM). Spiramycin is generally safe; potential side effects are usually mild and include nausea, vomiting, diarrhea, abdominal discomfort, or occasional skin rashes. Do not stop the medication without a specialist's confirmation.