Cold hands and feet with fatigue may be caused by conditions such as vitamin B12 deficiency, anaemia, thyroid issues, or poor circulation. Mecofol OD tablets contain Methylcobalamin and may help if your symptoms are due to vitamin B12 deficiency. It is generally safe when taken once daily as prescribed, but it may not be effective if the underlying cause is different. It is advisable to consult your doctor and undergo blood tests to confirm the cause before starting regular use.