Yes, Melano TX can affect your menstrual cycle. The active ingredient in Melano TX is Tranexamic Acid, which is primarily a medication used to reduce blood loss and treat heavy menstrual bleeding. When you double the dose, it can alter your normal menstrual flow, sometimes leading to a delayed, lighter, or missed period. First, please take a home pregnancy test if there is any possibility of pregnancy. If negative, the delay is likely due to the increased dosage. You should contact your dermatologist to discuss this side effect, and consult a gynecologist to ensure your menstrual health is safely monitored.