It is highly dangerous to stop beta-blockers like Metolar XR abruptly, as this triggers rebound high blood pressure and uneasiness. Metolar XR 25 is a standard medication, but extended-release (XR) tablets are typically prescribed once daily. Your uneasiness and blood pressure spikes indicate that your current regimen may need adjustment, or you might be experiencing withdrawal when skipping doses. Please do not stop or alter your medication on your own. Consult your cardiologist promptly to review your dosage, ensure proper 24-hour blood pressure control, and discuss if a different medication or once-daily dosing is better suited for you.