Yes, there are more affordable alternatives. Minirin contains the active ingredient desmopressin. A direct, lower-cost option is switching to a generic desmopressin nasal spray. Alternatively, desmopressin is available as oral tablets or sublingual (under-the-tongue) melts, which are often cheaper and more convenient. In some cases, other oral medications like thiazide diuretics might be considered, though they work differently. Please do not change your medication on your own. Consult your endocrinologist to discuss switching to generic desmopressin tablets or a generic spray, as they will need to adjust your dosage and monitor your fluid balance and sodium levels during the transition.