Yes, this combination is appropriate and commonly prescribed for anxiety, low confidence, and insomnia. Sertraline helps improve your mood and confidence over time. Mirtazapine and Clonazepam work together to target severe anxiety and improve sleep, though Clonazepam is generally used for short-term relief. Propranolol helps control physical symptoms of anxiety, such as a racing heart. While this combination is effective and safe under medical supervision, these medications can cause increased drowsiness or dizziness when combined. Please follow your doctor's instructions closely, avoid alcohol, and consult them if you experience excessive daytime sleepiness. Do not stop any medication abruptly.