A persistent 105 degrees F fever despite taking powerful antibiotics like Meropenem (Mero) and Ceftriaxone (Monocef) is a medical emergency. This suggests highly drug-resistant typhoid (XDR) or a potential misdiagnosis. Do not attempt to self-medicate with alternative drugs. You must go to a hospital emergency room immediately or urgently consult an infectious disease specialist. You need urgent blood cultures and sensitivity testing to identify the exact bacteria and find an effective treatment. Hospitalisation is critical for intravenous fluids, active temperature control, and close monitoring to prevent severe, life-threatening complications like intestinal perforation.