Since osmotic laxatives like Pegalup and Movicol are ineffective despite normal test results, you may have Irritable Bowel Syndrome with Constipation (IBS-C) or pelvic floor dysfunction. Please consult your doctor about these prescription alternatives: Secretagogues/Prokinetics: Medications like Linaclotide or Lubiprostone increase intestinal fluid to ease bowel movements and reduce pain. Prucalopride can help stimulate bowel motility. Gas and Pain Relief: Simethicone helps break down gas bubbles to relieve bloating, while mild antispasmodics can reduce stomach cramps.\n3. Probiotics: High-quality probiotics may help regulate gut flora. Do not start these prescription medications without your doctor's guidance.