For immediate relief of shifting pain in your hands and back, over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen can effectively reduce pain and inflammation. If these are insufficient, a doctor can prescribe stronger NSAIDs such as celecoxib or meloxicam. For severe inflammatory flare-ups, a short course of oral prescription corticosteroids, like prednisone, offers rapid relief. If muscle spasms are present in your back, prescription muscle relaxants like cyclobenzaprine may also help. Since shifting pain can sometimes indicate an underlying inflammatory or joint condition, please consult a healthcare professional for a proper evaluation and a personalised treatment plan.