It's important to know the exact type of infection you have before using any spray. Some sprays are meant for fungal infections, others for bacterial infections, and some might not be suitable for sensitive areas like around the anus. If you can tell me the name of the spray or the active ingredients, I can help you better. Meanwhile, keeping the area clean and dry is helpful, and if the infection is painful, spreading, or not improving, please see a doctor for proper diagnosis and treatment.