Taking Rabeprazole and Levosulpiride (Neopride Total) long-term is generally not recommended. While Rabeprazole manages acid, long-term Levosulpiride use carries risks of neurological side effects (like tremors or movement disorders) and hormonal imbalances. It should only be used for short durations under a doctor's supervision.\n\nBetween Rabeprazole and Pantoprazole, both are highly effective and have similar safety profiles. However, Pantoprazole is often considered slightly safer if you are taking multiple other medications, as it has a lower risk of drug-drug interactions. Always consult your doctor to find the safest long-term treatment plan for your acid reflux.