Neurotrat LM, which contains active B-vitamins, is generally safe, but taking it long-term alongside antidepressants and blood pressure medications requires medical supervision. Some B-vitamins can interact with specific antidepressants or affect blood pressure. Since your pain returned after stopping, it suggests an underlying issue like neuropathy or a nutritional deficiency that needs a formal diagnosis. Do not take it continuously without consulting your prescribing doctor. They must review your complete medication list to ensure there are no adverse drug interactions and determine if a daily, long-term regimen is safe and truly beneficial for your specific condition.