Since previous treatments failed, we must identify the underlying cause. Chronic itch can stem from internal conditions (like liver, kidney, or thyroid issues), nerve dysfunction, or systemic allergies. Therefore, a single 'cure-all' medicine cannot be prescribed safely without diagnostic tests. I highly recommend consulting a dermatologist or allergist. Depending on their findings, they may prescribe targeted treatments like gabapentin (for nerve-related itch), immunosuppressants, or suggest phototherapy (UV light). For immediate relief, use thick, fragrance-free moisturizers and over-the-counter lotions containing pramoxine or menthol to soothe the skin. Please avoid scratching to prevent secondary skin infections.