Nexfolin and Flydep-20 are prescribed together for patients suffering from Major Depressive Disorder (depression). Flydep-20 (an antidepressant, typically fluoxetine) helps regulate mood-balancing chemicals in the brain. Nexfolin (L-methylfolate) is an active form of vitamin B9 prescribed as an add-on therapy. It is used when standard antidepressants alone do not provide sufficient relief, or if there is an underlying folate deficiency. Together, Nexfolin enhances the brain's response to Flydep-20, making the antidepressant treatment more effective and helping to relieve stubborn depressive symptoms. Always take these medications exactly as prescribed by your healthcare provider.