It is frustrating when treatment doesn't bring relief. Since esomeprazole has not resolved your symptoms, your doctor might suggest switching to another acid-suppressor like rabeprazole or pantoprazole. Adding a prokinetic medication like itopride or domperidone can help reduce regurgitation and belching by speeding up stomach emptying. For immediate relief of throat discomfort, an alginate-based syrup can be very helpful.\n\nPlease do not self-medicate. I highly recommend consulting your gastroenterologist. They may suggest further evaluation, such as an endoscopy, to check your esophagus and tailor the most effective treatment plan for you.