Yes, sexual dysfunction is a common, well-documented side effect of Nexvenla OD 50 (desvenlafaxine), even during long-term use. Please do not stop or alter your dosage suddenly, as this can cause severe withdrawal symptoms.To manage this, consult your prescribing doctor. They may recommend several strategies, such as:1. Gradually reducing your dosage under medical supervision.2. Switching to a different antidepressant with fewer sexual side effects (like bupropion or mirtazapine).3. Adding an adjunctive medication to counteract the side effects.Your doctor will help find the safest option to improve your quality of life while maintaining your mental health.