No, you should not take Nifty SR for vaginal itching. Nifty SR contains nitrofurantoin, an antibiotic specifically used to treat urinary tract infections (UTIs) and will not treat vaginal infections. Vaginal itching is most commonly caused by a yeast (fungal) infection, bacterial vaginosis, or irritation. Taking an antibiotic when it is not needed will not cure these issues and can actually worsen a yeast infection by disrupting the healthy balance of bacteria in your vagina. Please consult your healthcare provider or a gynecologist for a proper diagnosis and the correct treatment, which may require an antifungal medication.