Two years of persistent acne suggest you need a targeted treatment plan. For mild acne, over-the-counter washes containing salicylic acid or benzoyl peroxide can help clear pores and reduce bacteria. For moderate to severe acne, prescription-strength treatments are highly effective; these include topical retinoids (like tretinoin), topical or oral antibiotics, or hormonal treatments. Because the right medicine depends entirely on your specific skin type and the severity of your acne, I highly recommend consulting a dermatologist. They can examine your skin and prescribe a safe, tailored regimen to clear your skin and prevent long-term scarring.