Please stop taking Nise immediately. Daily use of this painkiller for two years is highly unsafe and can cause serious kidney, liver, and stomach damage. Your severe eye pain is likely due to digital eye strain, dry eyes, or an outdated glasses prescription.Instead of oral painkillers, use over-the-counter lubricating eye drops (like Carboxymethylcellulose 0.5%) 4 times a day to relieve dryness. Follow the 20-20-20 rule: every 20 minutes, look at something 20 feet away for 20 seconds.Most importantly, please consult an ophthalmologist immediately for a comprehensive eye exam to rule out serious conditions and update your prescription.

Since it hasn't responded to nimesulide or stretching, the pain might stem from conditions like Achilles tendinopathy, a chronic ligament strain, or plantar fasciitis, which commonly causes pain upon waking. Sometimes, deep pressure can actually irritate these sensitive tissues further. I highly recommend seeing an orthopedic specialist. They can evaluate your ankle and may suggest an imaging study, like an ultrasound or MRI, to pinpoint the exact cause and guide you toward a safe, effective recovery plan.

It is safe for you to get a COVID-19 vaccine, as they do not contain paracetamol. You can safely receive any approved vaccine. To check for other allergies, you can review the vaccine's ingredient list?specifically looking for components like polyethylene glycol?with an allergist. If you develop a fever after the shot, NISE (nimesulide) can be used as an alternative to paracetamol, provided you have no contraindications to non-steroidal anti-inflammatory drugs. Please consult your doctor before taking NISE to ensure it is completely safe for your personal health profile.

Taking Nise (nimesulide) for just two days is very unlikely to cause your period to be late. Nimesulide is an anti-inflammatory painkiller, and while these medications can sometimes mildly affect ovulation, a short course rarely impacts your menstrual cycle. Often, the physical stress of the underlying pain or illness that prompted you to take the medication is the actual reason for the delay. Please try not to worry. If your period is delayed by more than a week, a quick home pregnancy test or a chat with your doctor can provide peace of mind.

Taking Nise (which contains nimesulide) daily over a long period can carry risks for your stomach and liver, so it should be monitored closely. Since your joint and back pain are worsening, it is very important to consult a healthcare professional. They can properly evaluate your heel, knee, and old wrist fracture to find the root cause of the inflammation. A doctor can guide you on safer, long-term treatment plans, which might include targeted physical therapy and gentler medications, and let a doctor help you safely find relief.

Yes, it is entirely safe for you to get any approved COVID-19 vaccine, as none of them contain paracetamol. Since you have a paracetamol allergy, you can manage a post-vaccine fever with ibuprofen, which is a safe generic alternative. You can also take NISE (nimesulide) for fever and pain, provided you do not have any known allergies to nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen. Always stay well-hydrated, rest, and consult your doctor to confirm the safest option and correct dosage for your specific health history.