Stop taking Nucoxia MR immediately. Your symptoms suggest a severe, potentially life-threatening adverse drug reaction (like a Fixed Drug Eruption or Stevens-Johnson Syndrome). This is a medical emergency. Candid B and Tramadol are not helping because this reaction requires immediate hospital-level evaluation, not self-medication. Please go to the nearest emergency department or see a dermatologist right away. They will evaluate you for specialized wound care, intravenous fluids, and appropriate pain management medications. Do not apply any more creams or take further pain relievers until evaluated by a doctor.