What could be the underlying cause of my chronic "pressing" and burning pain in my body, legs, and buttocks that started after an ankle injury in 2009?which also causes indigestion, eye burning, and a feverish feeling?and why has it not improved despite a normal leg circulation test (Doppler) and treatments with Vitamin D3, Vitamin B12, Sulfasalazine, Coerip, Boswellia, Duloxetine, Amitriptyline, Pregabalin, and Nurokind?
Since your vascular tests are normal and standard nerve medications like pregabalin, duloxetine, and amitriptyline haven't fully helped, your symptoms?especially the burning pain, eye warmth, and indigestion?suggest a potential systemic or autonomic nerve involvement, such as small fiber neuropathy or central sensitization. Sometimes, a past injury can trigger the nervous system to remain hyperactive. I highly recommend consulting a neurologist or a specialized pain clinic to evaluate you for small fiber neuropathy, possibly through a skin biopsy.