What clinical investigations or differential diagnoses should be considered for a patient presenting with a 25-day history of persistent sore throat, low-grade fever (99?99.4?F) with nocturnal sweating, and severe weakness, which has remained unresponsive to multiple courses of antibiotics (including amoxicillin, co-amoxiclav, ofloxacin, and azithromycin) and antiseptic gargles, despite normal CBC, LFT, KFT, Typhi-dot, and chest X-ray results? | Apollo Pharmacy

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What clinical investigations or differential diagnoses should be considered for a patient presenting with a 25-day history of persistent sore throat, low-grade fever (99?99.4?F) with nocturnal sweating, and severe weakness, which has remained unresponsive to multiple courses of antibiotics (including amoxicillin, co-amoxiclav, ofloxacin, and azithromycin) and antiseptic gargles, despite normal CBC, LFT, KFT, Typhi-dot, and chest X-ray results?

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What clinical investigations or differential diagnoses should be considered for a patient presenting with a 25-day history of persistent sore throat, low-grade fever (99?99.4?F) with nocturnal sweating, and severe weakness, which has remained unresponsive to multiple courses of antibiotics (including amoxicillin, co-amoxiclav, ofloxacin, and azithromycin) and antiseptic gargles, despite normal CBC, LFT, KFT, Typhi-dot, and chest X-ray results?

Asked by Male, 20 · 13 days ago

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

13 days ago

Since your symptoms have not responded to antibiotics like amoxicillin or azithromycin, and your initial tests are normal, we should look beyond common bacterial infections. It would be wise to consult your doctor about testing for viral infections such as infectious mononucleosis (Epstein-Barr virus) or cytomegalovirus, which often cause prolonged sore throat and fatigue. Given the night sweats, an HIV screening, throat culture, or a thyroid function test may also be helpful. Rest assured, identifying the precise cause is the first step to helping you feel better. I highly recommend consulting an ENT specialist or an infectious disease physician.

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What clinical investigations or differential diagnoses should be considered for a patient presenting with a 25-day history of persistent sore throat, low-grade fever (99?99.4?F) with nocturnal sweating, and severe weakness, which has remained unresponsive to multiple courses of antibiotics (including amoxicillin, co-amoxiclav, ofloxacin, and azithromycin) and antiseptic gargles, despite normal CBC, LFT, KFT, Typhi-dot, and chest X-ray results?

Answered 13 days ago

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