After using OptiZette Plus, puffiness around the eyes and itching could indicate an allergic response or irritation. For the time being, you should cease using the drops and gently cleanse your eyes with clean water without rubbing them. To lessen swelling, apply a cold compress. Do not use any other eye drops unless prescribed by a physician. It's crucial to get in touch with your eye doctor as soon as possible so they can examine your eyes and adjust your therapy if necessary because eye swelling can occasionally get worse.