Since pantoprazole with domperidone isn't providing relief, first ensure you are taking it on an empty stomach, 30 to 60 minutes before breakfast. If you are already doing this, your doctor might suggest switching to alternative generic medications, such as esomeprazole or rabeprazole (often paired with a prokinetic like itopride), or an H2-blocker like famotidine. Persistent acidity despite medication requires a proper medical evaluation to check for underlying causes like H. pylori infection. Please consult your healthcare provider to safely adjust your prescription and discuss if further diagnostic tests, like an endoscopy, are necessary.