Mild lower abdominal pain can be normal as your body changes to accommodate your growing baby. For mild discomfort, acetaminophen (paracetamol) is generally considered the safest pain reliever during pregnancy. You should avoid nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. Because abdominal pain can sometimes indicate other conditions, it is very important to consult your obstetrician before taking any medication. Please seek immediate medical care if the pain becomes severe, constant, or is accompanied by vaginal bleeding, fluid leaking, or fever.