A high fever of 104.6F is significant and should be evaluated by a doctor. Basic tests usually recommended include CBC (complete blood count), malaria test, dengue test (NS1/IgM), typhoid test, and urine routine examination. Meanwhile, give paracetamol for the fever and keep her well hydrated. Seek medical care if the fever persists or worsens.

Since you have had a fever for 15 days with chills, headache, weakness, and poor appetite, you need proper blood tests to find the cause. Do not keep changing medicines on your own. Please consult a physician with all your reports so the exact cause can be identified and treated properly.

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A sudden move from a cold to a hot, humid climate can sometimes cause mild fatigue or heat exhaustion, but it usually does not cause a high fever. Since she had multiple mosquito bites and now has fever with weakness, a mosquito-borne infection like dengue or malaria should be considered if the fever persists. Monitor her temperature, keep her well hydrated, and give paracetamol if needed.

Fever that comes mainly at night can be due to viral or bacterial infections. Monitor your temperature, stay hydrated, and take paracetamol if needed. If it lasts more than 2 to 3 days or is very high with chills or weakness, see a doctor for proper tests and treatment.