It is important that any change in your mother's paroxetine dose is guided by her doctor to ensure safety and effectiveness. Increasing from 12.5 mg to 25 mg daily can be appropriate but should be done under medical supervision, especially considering her age.

• Current effectiveness and tolerance: If she is responding well to 12.5 mg without significant side effects, her doctor may consider a cautious increase.
• Safety of dose increase: Paroxetine at 25 mg daily is commonly prescribed, but older adults may be more sensitive to side effects like dizziness, fatigue, or gastrointestinal symptoms.
• Medical supervision: Always consult her psychiatrist or prescribing physician before adjusting the dose to tailor it to her specific health status.
• Monitoring: After increasing the dose, watch for new or worsening side effects such as increased drowsiness, mood changes, or any unusual symptoms.
• Alternatives and adjustments: Sometimes a gradual increase or alternative therapies may be recommended depending on her response.

Please encourage her to discuss this with her prescribing doctor to ensure the safest approach. If you want, I can explain potential side effects or monitoring tips in more detail.