I understand your frustration. Since your current regimen (Petril Plus and Mirtaz 7.5) isn?t providing relief, please consult your psychiatrist before making any changes. Do not stop these medications abruptly. Your doctor may consider adjusting the doses or switching to alternative options like SNRIs (e.g., Duloxetine) or Bupropion. For lifestyle support, aim for 30 minutes of daily moderate exercise, maintain a strict sleep schedule, and limit alcohol and caffeine. Combining medical treatment with Cognitive Behavioural Therapy (CBT) is also highly effective for treatment-resistant depression. Please schedule a follow-up to safely optimise your plan.