Yes, you can take these medications, but close medical supervision is necessary. Your blood pressure medication (amlodipine) is generally safe for kidneys. However, with a creatinine level of 1.8, your kidneys clear medications more slowly. This can cause paroxetine and clonazepam to accumulate in your body, increasing the risk of side effects like excessive drowsiness or dizziness. Fortunately, your prescribed doses (paroxetine 12.5 mg and clonazepam 0.25 mg) are low, which is safer for reduced kidney function. Please ensure your prescribing doctor is fully aware of your kidney status so they can monitor your kidney function and adjust doses if needed. Do not alter your doses without medical advice.