Yes, it is generally safe and highly advisable to continue your prescribed medications, prazosin, telmisartan, and amlodipine, on a long-term basis. These medicines are designed to manage chronic conditions like high blood pressure daily. Feeling unwell when you stop taking them is a natural response, as your blood pressure can suddenly spike back up (rebound hypertension). For your safety, never stop these medications abruptly. They are safe for long-term use, but you should have regular check-ups with your doctor to monitor your kidneys, electrolytes, and blood pressure to ensure the treatment remains safe and effective for you.