If Pregabalin did not suit you, other options for nerve pain in the leg include Gabapentin, duloxetine, or certain B?vitamins prescribed by your doctor. Non-drug measures like gentle stretching, warm compresses, proper foot care, and controlling underlying conditions (like diabetes) can also help. Consult your doctor to find the safest and most effective alternative for your situation.

Since you have been on mecobalamin, epalrestat, and pregabalin for diabetic neuropathy for a year, it is important to review your treatment with your doctor. They may suggest dose adjustments, other medications or additional therapies such as physical therapy or lifestyle changes. Keeping your blood sugar well-controlled is also crucial to prevent worsening neuropathy.

A burning sensation and discomfort in the foot can have several possible causes, including nerve-related issues such as peripheral neuropathy (often seen in diabetes or vitamin deficiencies), poor circulation, infections, injuries, or conditions like tarsal tunnel syndrome or plantar fasciitis. Other contributing factors can include prolonged pressure on the foot, certain medications, or systemic conditions affecting nerves or blood vessels. Because the cause can range from mild to serious, it is important to consult a doctor or podiatrist for a proper evaluation, diagnosis, and treatment plan.