It is very common to try a few options before finding the right treatment. Since Pristiq 50 mg and Taloprex have not worked, you can discuss these alternatives with your doctor: 1. Switching Medications: Try a different class of antidepressant, such as mirtazapine, bupropion, or a different SSRI like sertraline. 2. Augmentation: Adding a secondary medication, such as buspirone for anxiety, or a low-dose atypical antipsychotic like aripiprazole to boost effectiveness. 3. Psychotherapy: Combining medication with Cognitive Behavioural Therapy (CBT) is highly effective for managing racing thoughts and fear. Please consult your doctor to safely transition to a new treatment plan.