Taking one extra dose of Progynova (estradiol valerate) so close to your last one is very unlikely to cause any serious harm. You might experience some mild, temporary side effects like a bit of nausea, breast tenderness, a mild headache, or light spotting, but these should pass quickly. You can simply resume your regular three-times-a-day schedule with your next planned dose. Try to keep your doses spaced out as evenly as possible going forward.

What you are experiencing is completely normal and very common after a frozen embryo transfer. The powdery discharge is most likely residue from your vaginal progesterone (Susten) tablets dissolving. Meanwhile, the clear, watery discharge is typically caused by increased estrogen levels from Progynova, which naturally increases vaginal secretions. This is a very common side effect of your support medications and is not a sign of PMS or that the transfer has failed. Please continue taking your medications exactly as prescribed by your doctor.

Taking your 9:00 AM Progynova (estradiol valerate) 2.5 hours late at 11:30 AM will not affect its effectiveness, as a small delay like this is perfectly fine. You should absolutely still take your scheduled 9:00 PM dose tonight at its normal time. There is no need to skip it or change your schedule. Moving forward, just try to take your doses as close to your regular times as possible to keep your hormone levels steady.

Regarding Progynova (estradiol valerate), taking 12 mg daily in your first trimester is a specialized dose, but it is routinely prescribed in assisted pregnancies to support the uterine lining and maintain the pregnancy. Under medical supervision, estradiol valerate is safe and is not associated with an increased risk of congenital birth defects. Your medical team has carefully chosen this to support your remaining pregnancy. Please continue to follow your specialist's guidance, and do not hesitate to reach out to them with any concerns.

It is definitely possible for you to get pregnant this cycle. An egg size of 20 mm on day 10 is excellent, indicating a mature follicle ready for ovulation, which your HCG injection will help trigger. While your womb lining is currently 5.8 mm, which is a bit thin, it is still early in your cycle. Your Progynova (estradiol) will continue to help thicken this lining over the next few days to prepare it for implantation. You are in a very promising position, and your body is responding well. Try to stay relaxed and positive.

You should talk to your doctor or gynaecologist about the pain you are experiencing, as they may adjust your Duphaston tablet (dydrogesterone) dosage or suggest an alternative progesterone with fewer side effects, such as Utrogestan. Do not stop or change the Duphaston tablet on your own, especially before IVF, as it is essential for preparing your womb lining.