An E2 (oestradiol) level of 104 is lower than usually desired for preparing the womb lining for an IVF cycle. The slow increase from 99 to 104 suggests your doctor may need to adjust the dosage of Progynova 1 mg Tablet (estradiol). Your doctor will use this result, along with an ultrasound scan, to determine the next steps in your wife's treatment plan.

Stem cell therapy is not a proven alternative to knee replacement, especially for severe arthritis. It may help mild cartilage damage, but results are variable and not guaranteed. For advanced knee degeneration, knee replacement remains the most reliable option.