It is very common to need a treatment review after 12 years. Since you are still experiencing tension and panic, and are facing side effects like weight gain and memory issues, it is highly advisable to consult your doctor about adjusting your treatment plan. Both quetiapine and amisulpride can sometimes contribute to weight gain and cognitive changes over long periods. Your doctor may safely adjust your dosages, discuss alternative treatments better suited for long-term anxiety and depression, or suggest therapy. Please do not make any changes on your own, as stopping these medications suddenly can cause withdrawal symptoms. Your doctor will guide you through a safe, gradual transition.