As a person with diabetes, your foot health is very important. You should avoid over-the-counter medicated callus removers (such as salicylic acid liquids or patches) and sharp tools, as they can easily cause irritation, chemical burns, or sores. Instead, you can safely apply a gentle moisturizing cream containing urea or ammonium lactate to help soften the hardened skin. Be sure to avoid applying cream between your toes to prevent excess moisture. The safest and most effective approach is to have a podiatrist or your doctor gently trim the callus for you. In the meantime, wear comfortable, supportive shoes to reduce pressure on the area.